STJ130025
HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) tyrosine kinase family. Heterodimerisation of HER2 with another family member leads to stimulation of cell proliferation and suppression of apoptosis via its downstream signal pathways. Amplification or over-expression of HER2 has been demonstrated to play a critical role in the development and progression of mangy aggresive types of tumors. Recently, the protein has become a key biomarker and leading therapeutic target of various cancers.
727.8 €