Anti-Factor XIIIa antibody

YF-PA11674

anti-Factor XIIIa

Mouse polyclonal to Factor XIIIa

435.6 €

YF-PA11675

anti-Factor XIIIa

Rabbit polyclonal to Factor XIIIa

483.6 €

ER1902-34

Anti-Factor XIIIa Antibody

This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.

433.5 €

PAab02938

Anti-Factor XII antibody

711.2 €

PAab02939

Anti-Factor XII antibody

17081 €

E38A6601

Anti-Factor XII LC Antibody

Available in various conjugation types.

487.5 €