Anti-CHOP antibody
504.6 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 665 - STJ97774
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 200 µl
STJ97774
Anti-CHOP antibody
CHOP is a protein encoded by the DDIT3 gene which is approximately 19,1 kDa. CHOP is localised to the cytoplasm and nucleus. It is involved in the unfolded protein response, the MAPK signalling pathway and apoptosis modulation and signalling. This protein falls under the CCAAT/enhancer-binding protein family of transcription factors. It functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP and preventing their DNA binding activity. It is activated by endoplasmic reticulum stress and promotes apoptosis. CHOP is expressed in the muscle, nervous system, eye, liver and heart. Mutations in the DDIT3 gene may result in myxoid liposarcoma. STJ97774 was developed from clone 2B1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody detects endogenous levels of DDIT3
504.6 €
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