Because of the high levels of plasma-protein binding exhibited by WM-8014, WM-8014 can?t be used in vivo in mice. Development of derivatives of WM-8014 resulted in WM-1119, which has reduced plasma-protein binding.
Because of the high levels of plasma-protein binding exhibited by WM-8014, WM-8014 can?t be used in vivo in mice. Development of derivatives of WM-8014 resulted in WM-1119, which has reduced plasma-protein binding.