Catalog number: 544 - MBS440083-02mg
Product Category: Business & Industrial > Science & Laboratory
Size: 0.2mg
ABC-TC0230
The E11 cell line has been cloned from the outgrowth of glomeruli which were isolated from H-2kb-tsA58 transgenic mice. The mice carry a temperature-sensitive variant of the SV40 large T antigen under control of the IFN-g-inducible H-2kb promoter. Cells proliferate at 33°C, and they differentiate at 37°C. At present, the cells have been cultured successfully for more than 40 passages without noting phenotypic changes.The species was confirmed by Real-Time PCR.
M1306-3
This gene encodes a member of the neurexophilin family of neuropeptide-like glycoproteins. The encoded protein contains a variable N-terminal domain, a highly conserved neurexophilin and PC-esterase (NXPE) central domain, a short linker region, and a cysteine-rich C-terminal domain. This protein binds alpha neurexins, a group of presynaptic transmembrane receptors that promote adhesion between dendrites and axons. Alternative splicing results in multiple transcript variants.
M1405-8
Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication. Crystal structure data suggests that a PCNA homotrimer ring can encircle and slide along the DNA double helix. Multiple proteins involved in DNA replication, DNA repair, and cell cycle control bind to PCNA rather than directly associating with DNA, thus facilitating fast processing of DNA. PCNA protein expression is a well-accepted marker of proliferation.
M0809-12
Transthyretin (TTR) originally called prealbumin is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol. Prealbumin concentrations are disproportionately high in human ventricular cerebrospinal fluid (CSF). Over 80 different disease-causing mutations in prealbumin have been reported. TTR is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC).