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TIGIT : CD155 [Biotinylated] Inhibitor Screening ELISA Kit
1074.92 €
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Catalog number: 716 - EP-131-96tests
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 96tests
![TIGIT : CD155 [Biotinylated] Inhibitor Screening ELISA Kit](/images/no-image-product-box.jpg "TIGIT : CD155 [Biotinylated] Inhibitor Screening ELISA Kit")
EP-131
TIGIT : CD155 [Biotinylated] Inhibitor Screening ELISA Kit
CD155 and ITIM domains (TIGIT) is a novel type of immune checkpoint. CD155 is an adhesion molecule that is upregulated during tumor progression and promotes the proliferative and migratory abilities of tumor cells via various pathways. TIGIT, an inhibitory receptor, is mainly expressed on natural killer (NK), CD8+ T, CD4+ T and T regulatory (Treg) cells. CD155 transmits immune signals via interacting with the inhibitory checkpoint receptor TIGIT, thereby inhibiting the function of T and NK cells.CD155 is highly expressed on the surface of DC cells. When TIGIT on T cells binds to CD155 on DC cells, CD155 will send signals to DC cells to up-regulate the secretion of IL-10 and down-regulate the secretion of IL-12, thereby weakening the immune response mediated by DC cells. DC cells are important antigen-presenting cells in the body, and reduced DC cell activity in turn reduces T cell activity.
1074.92 €
EP-131-96tests
TIGIT : CD155 [Biotinylated] Inhibitor Screening ELISA Kit
CD155 and ITIM domains (TIGIT) is a novel type of immune checkpoint. CD155 is an adhesion molecule that is upregulated during tumor progression and promotes the proliferative and migratory abilities of tumor cells via various pathways. TIGIT, an inhibitory receptor, is mainly expressed on natural killer (NK), CD8+ T, CD4+ T and T regulatory (Treg) cells. CD155 transmits immune signals via interacting with the inhibitory checkpoint receptor TIGIT, thereby inhibiting the function of T and NK cells.CD155 is highly expressed on the surface of DC cells. When TIGIT on T cells binds to CD155 on DC cells, CD155 will send signals to DC cells to up-regulate the secretion of IL-10 and down-regulate the secretion of IL-12, thereby weakening the immune response mediated by DC cells. DC cells are important antigen-presenting cells in the body, and reduced DC cell activity in turn reduces T cell activity.
1074.92 €
EP-118
BCMA [Biotinylated] : BAFF Inhibitor Screening ELISA Kit
TNFRSF17 is a member of the TNF-receptor family, known as tumor necrosis factor receptor superfamily member 17, also known as B cell maturation antigen (BCMA or BCM) or CD269. It is a protein encoded by TNFRSF17 gene. The receptor is expressed on the surface of B lymphocytes and plasma cells and is a marker protein of B lymphocyte maturation.The main ligands of BCMA are BAFF and APRIL. BCMA combined with BAFF could activate the classical and non-classical NF-κB and JNK signaling pathways, up-regulate the expression of anti-apoptotic protein and down-regulate the expression of pro-apoptotic protein. When BCMA binds to APRIL, the expression level of immune checkpoint is up-regulated, creating an immunosuppressed bone marrow microenvironment.
1074.92 €
EP-116
B7-1 [Biotinylated] : CTLA-4 Inhibitor Screening ELISA Kit
Cytotoxic T lymphocyte associated ANTIgen-4 (CTLA-4), also known as CD152, is a kind of leukocyte differentiation antigen and a transmembrane receptor on T cells, sharing B7 ligand with CD28. The binding of CTLA-4 with B7 induces T cells to be non-reactive and participates in the negative regulation of immune response. The recombinant CTLA-4 Ig can effectively and specifically inhibit cellular and humoral immune responses in vivo and in vitro, and has significant therapeutic effects on transplant rejection and various autoimmune diseases with very low toxicity. It is considered as a promising new immunosuppressive drug at present.
1074.92 €
EP-116-96tests
B7-1 [Biotinylated] : CTLA-4 Inhibitor Screening ELISA Kit
Cytotoxic T lymphocyte associated ANTIgen-4 (CTLA-4), also known as CD152, is a kind of leukocyte differentiation antigen and a transmembrane receptor on T cells, sharing B7 ligand with CD28. The binding of CTLA-4 with B7 induces T cells to be non-reactive and participates in the negative regulation of immune response. The recombinant CTLA-4 Ig can effectively and specifically inhibit cellular and humoral immune responses in vivo and in vitro, and has significant therapeutic effects on transplant rejection and various autoimmune diseases with very low toxicity. It is considered as a promising new immunosuppressive drug at present.
1074.92 €
EP-117
B7-2 [Biotinylated] : CTLA-4 Inhibitor Screening ELISA Kit
Cytotoxic T lymphocyte associated ANTIgen-4 (CTLA-4), also known as CD152, is a kind of leukocyte differentiation antigen and a transmembrane receptor on T cells, sharing B7 ligand with CD28. The binding of CTLA-4 with B7 induces T cells to be non-reactive and participates in the negative regulation of immune response. The recombinant CTLA-4 Ig can effectively and specifically inhibit cellular and humoral immune responses in vivo and in vitro, and has significant therapeutic effects on transplant rejection and various autoimmune diseases with very low toxicity. It is considered as a promising new immunosuppressive drug at present.