Recombinant Human ALK2 (N-GST tag)
3098.38 €
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Catalog number: 544 - MBS4160009-5x001mg
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 5x0.01mg
Z500010
Recombinant Human ALK2 (N-GST tag)
ALK 2 is a receptor serine/threonine kinase that is member of the ALK family and is upstream of signaling pathway involving the SMAD proteins especially SMAD1/5/8. Knockdown of ALK2, but not TGFßRI (ALK5), abrogates endoglin-mediated decrease in cell motility of prostate cancer cells and constitutively active ALK2 is sufficient to restore a low-motility phenotype in endoglin deficient cells . Therefore, endoglin decreases prostate cancer cell motility through activation of the ALK2-Smad1 pathway. ALK2 is the key gene involved in Fibrodysplasia ossificans progressiva (FOP), a rare autosomal dominant congenital disorder characterized by progressive heterotopic bone formation in muscle tissues .
671.00 €