A bispecific antibody that is expressed as an anti-Ang2 nanobody (VHH) fused with an anti-VEGFA nanobody (VHH), contains a His-tag at the C/N terminus for affinity purification. This BsAb is capable of inhibiting two proangiogenics fators. It is designed for the research of Colorectal cancer (CRC); Solid tumors; Wet AMD (Age-related macular degeneration); Diabetic macular edema therapy.