Rat Anti-Human CD197 (CCR7) Purified (100 ug)
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Catalog number: 937 - TA320232
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 100 µg
E16FHU197-025U
Purified anti-human CD197 (CCR7)
Available in various conjugation types.
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RD21847F-100Tests
FITC Anti-Human CD197/CCR7 Antibody
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Na?ve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details