HY-131183

PROTAC PD-1/PD-L1 degrader-1

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner[1].

5909.25 €

MBS5800413-10mg

PROTAC PD-1/PD-L1 degrader-1

1868.00 €

MBS5800413-5mg

PROTAC PD-1/PD-L1 degrader-1

1281.50 €

MBS5785098-25mg

PD-1/PD-L1-IN-NP19

1906.25 €

MBS5785098-50mg

PD-1/PD-L1-IN-NP19

2123.00 €

MBS5785098-5mg

PD-1/PD-L1-IN-NP19

663.12 €