Phospho-Catenin-Beta (S37) Polyclonal Antibody
484.80 €
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Catalog number: 965 - JOT-PHS00047-100ul
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 100ul
BT-PHS00047-100ul
Phospho-Catenin-Beta (S37) Polyclonal Antibody
Catenin beta 1 encoded by CTNNB1 is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta 1 also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, catenin beta 1 binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.
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MBS6412920-5x01mL
CTNNB1, Phosphorylated (S37) (Catenin beta 1, Catenin, beta, CTNNB, MRD19, Armadillo) (MaxLight 750)
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