PARP-3 (human), (recombinant) (high purity)
4531.87 €
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Catalog number: 544 - MBS566064-5x002mg
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 5x0.02mg
90-340
PARP-1 [ARTD1] high purity Recombinant Protein
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.