Myc Reporter (Luc) - HCT116 Cell Line (Myc Signaling Pathway)
3412.50 €
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Catalog number: 421 - 60520
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 2 vials
ABC-RC115D
Myc Report Cell Line(Luc)–HCT116 (Myc Signaling Pathway)
The Myc Reporter andndash; HCT116 cell line contains the firefly luciferase gene under the control of Myc responsive elements stably integrated into HCT116 cells, a human colon cancer cell line. HCT116 contains a mutated beta-catenin which leads to the accumulation of andbeta; -catenin and constitutive activation of downstream Myc that induces the expression of Myc luciferase reporter. The cell line is validated for the inhibition of the expression of Myc luciferase reporter.
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60623
NF-κB Reporter (Luc) - HCT116 Cell Line
NF-B luciferase reporter construct is stably integrated into the genome of HCT-116 cells. The<br />firefly luciferase gene is controlled by 4 copies of NF-κB response element located upstream of<br />the TATA promoter. Following activation by stimulants, endogenous NF-κB transcription factors<br />bind to the DNA response elements to induce transcription of the luciferase gene._x000D_The NF-κB-luciferase/HCT-116 cell line is suitable for monitoring the activity of NF-κB signaling<br />in response to stimulants such as the cytokines TNF and IL-1β, pathogen-associated<br />molecular pattern (PAMP) (i.e. flagellin) or endogenous damage-associated molecular pattern<br />(DAMP) molecules (i.e. NOD1 ligand) (see application references). It is also suitable for<br />establishing cell-based screens for inhibitors that target specific NF-κB stimulating molecules.<br />This cell line can be further modified to allow investigation of downstream NF-κB activities as a<br />result of targeted genetic mutation(s).
1792.50 €
60515
CRE/CREB Reporter (Luc) - HEK293 Cell Line (cAMP/PKA Signaling Pathway)
The cAMP/PKA Signaling Pathway CRE/CREB Reporter (Luc) - HEK293 Cell Line is designed for monitoring the activity of the cAMP/ PKA signaling pathway. The cAMP/PKA Signaling Pathway CRE/CREB Reporter (Luc) - HEK293 Cell Line contains a firefly luciferase gene under the control of multimerized cAMP response element (CRE) stably integrated into HEK293 cells. Elevation of the intracellular cAMP level activates cAMP response element binding protein (CREB) to bind CRE and induces the expression of luciferase.
3255.00 €