IC50: 0.65 nM for both A?(40) and A?(42) MRK-560 is a novel ?-secretase inhibitor.?-Secretase is a member of the I-CLiP protease family and is reported to cleave a number of additional intramembrane substrates, including Erb4, CD-44, Notch, E-cadherin, and the Notch ligands.
IC50: 0.65 nM for both A?(40) and A?(42) MRK-560 is a novel ?-secretase inhibitor.?-Secretase is a member of the I-CLiP protease family and is reported to cleave a number of additional intramembrane substrates, including Erb4, CD-44, Notch, E-cadherin, and the Notch ligands.