Mouse MBL-2 / MBL Protein (His Tag)
758.75 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 544 - MBS2547244-005mg
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 0.05mg
MBL-H5220
Human MBL Protein, His Tag
Human MBL, His Tag (MBL-H5220) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Ile 248 (Accession # P11226-1).
528 €
55-1008
MBL Oligomer ELISA Kit
ELISA Kit for the determination of oligomerized Mannan-binding lectin (MBL) in human serum or heparin plasma
1718.4 €
101-M562
Anti-Human MBL Antibody
Human mannose/mannan-binding lectin (MBL; also MBPC) is a 25 kDa member of the collectin family of pattern-recognition molecules. It is a secreted glycoprotein that is synthesized as a 248 amino acid (aa) precursor that contains a 20 aa signal sequence, a 21 aa cysteinerich region (with three cysteines) a 58 aa collagenlike segment and a 111 aa Ctype lectin domain that binds to neutral bacterial carbohydrates. The molecule is O glycosylatedand contains multiplehydroxylated prolines and lysines. Functionally, the molecule operates as a multimer/oligomer. The basic structural unit is a homotrimer. The homotrimer iscreated by the formation of interchain disulfide bonds among the cysteinerichregions, plus a helical interaction of the collagen-like domains of each participating polypeptide. Mutations in the collagen region are known to interfere with proper trimer and subsequent oligomer formation. Once formed, the trimer, as a unit, oligomerizes with other trimers to form high molecular weight complexes. Although the exact nature of these complexes are unclear, it would appear that a three trimer complex (230 kDa) and a four trimer complex (305 kDa) constitute much of the circulating MBL. It is within the context of these oligomers that MBL performs its functions. After secretion by hepatocytes, oligomerized MBL will both associate with serine proteases (MASP1, 2 & 3) and bind to bacterial carbohydrates. If the MBL complex is small, opsonization of bacreria occurs. If the complex is large, the MASPs are engaged and a complement attack complex is generated, destroying bound bacteria. Human MBL is 63%, 61% and 65% aa identical to mouse, porcine and bovine MBL, respectively.