GIR-C52H6

Canine GITR / TNFRSF18 Protein, His Tag

Canine GITR, His Tag (GIR-C52H6) is expressed from human 293 cells (HEK293). It contains AA Gly 23 - Pro 154 (Accession # D7F619-1).

3598.19 €

GIR-M5220

Mouse GITR / TNFRSF18 Protein, His Tag

Mouse GITR, His Tag (GIR-M5220) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - His 153 (Accession # Q8C4K3).

665.39 €

GIR-R5222

Rat GITR / TNFRSF18 Protein, His Tag

Rat GITR, His Tag (GIR-R5222) is expressed from human 293 cells (HEK293). It contains AA Gln 20 - Lys 121 (Accession # Q5M835).

586.12 €

GIR-H525a

Human GITR / TNFRSF18 Protein, Mouse IgG2a Fc Tag, low endotoxin

Human GITR Protein, Mouse IgG2a Fc Tag (GIR-H525a) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Glu 161 (Accession # Q9Y5U5-1).

3109.39 €

MBS8432140-INQUIRE

Human GITR/TNFRSF18 Recombinant Protein Mouse IgG Fc Tag Lyophilized

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SFC-001

Human GITR/TNFRSF18 Fc Recombinant Protein

GITR, also known as tumor necrosis factor receptor superfamily 18 (TNFRSF18), is a member of the receptor family bearing the same name that is expressed on the surfaces of cells involved in both adaptive and innate immunity, including CD4+ T cells, CD8+ T cells, natural killer cells, B cells, macrophages, and dendritic cells. Like all other TNFRSF members, GITR regulates the duration, phenotype, and degree by which the immune system responds to antigens. The National Cancer Institute regards GITR as the 12th most important molecule involved in immunotherapy, as it plays a major role in modulating both inflammatory and immune responses. The receptor has attracted the attention of immunologists for its potential as a costimulatory immune checkpoint molecule in immunotherapy. Expressed in peripheral tissues as well as endothelial cells, GITR inhibits T cell receptor-induced apoptosis via its cross-linking mechanism, thereby creating an environment that promotes T cell longevity and survival. To accomplish this task, GITR initiates signal transduction by activating nuclear factor κB (NF-κB) along with the following specific mitogen-activated protein kinase (MAPK) pathways: extracellular signal-related kinases (ERKs), c-Jun N-terminal kinase (JNK), and p38. Several bone disorders, such as familial expansive osteolysis, autosomal recessive osteopetrosis and Paget’s disease, have been attributed to GITR mutations due to its key role in regulating osteoclast and lymph node development. The CHO cell-derived Recombinant Human GITR/TNFRSF18 Fc is a glycosylated, disulfide-linked homodimer of 738 amino-acid-residues whose monomer consists of a 136-amino-acid extracellular domain fused to the 231-amino-acid length Fc portion of human IgG by two glycine residues. The calculated molecular weight of monomeric CHO cell-derived Recombinant Human GITR/TNFRSF18 Fc is 40.6 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 45-50 kDa by SDS-PAGE analysis under reducing conditions.

448.96 €