ABC-TC3594

Human Dermal Microvascular Endothelial Cells

Blood vessels of the skin are composed of a number of cellular and non-cellular elements. The predominant cell type in all skin blood vessels is the endothelial cell. Endothelial cells form the interface between intravascular and extravascular compartments and serve as a selective barrier for the diffusion of cells and macromolecules between these two compartments. The endothelial cells lining blood vessels of the skin share features of endothelial cells elsewhere in the body, but they also exhibit several skin specific characteristics. They are active participants in a variety of physiological processes. These include wound healing, control of hemostasis, temperature regulation, and the modulation of inflammation/leukocyte trafficking. The structure and function of endothelial cells are differentially regulated in space and time. Endothelial cell proliferation, quiescence, apoptosis, and senescence are the four principal cytologic states that set the cutaneous microvascular in a dynamic balance between maintenance and remodeling.HDMEC from Gentaur Research Laboratories are isolated from human dermal tissue. HDMEC are cryopreserved on passage one and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HDMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CD31 (P-CAM) and by uptake of DiI-Ac-LDL. HDMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HDMEC are guaranteed to further expand for 15 population doublings in the conditions provided by Gentaur Research Laboratories.

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ABC-TC4125

Rat Dermal Microvascular Endothelial Cells

Rat Dermal Microvascular Endothelial Cells are isolated from tissue of 1-day-old neonatal Sprague-Dawley rats. Rat Dermal Microvascular Endothelial Cells are grown in T75 tissue culture flasks pre-coated with 0.2% gelatin for 1 hour and incubated in Culture Complete Growth Medium.

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cAP-m0004

Mouse Dermal Microvascular Endothelial Cells

1051.41 €

ABC-TC3476

Human Adipose Microvascular Endothelial Cells

Microvascular endothelial cells line blood vessels and contribute to many biological processes such as angiogenesis, coagulation, trafficking of lymphocytes, and the inflammatory response. Microvascular endothelial cells are diverse and have specific cellular characteristics and functions depending on the organ/tissue in which they are found. Adipose tissue is unique because it has the capacity to continually grow throughout adult life. It thus has a high occurrence of angiogenesis in order to provide the extensive vascularization require for adipose tissue. Studies have shown that angiogenesis precedes adipogenesis, implying that microvascular endothelial cells influence the proliferation of preadipocytes. Microvascular endothelial cell growth is at the same time stimulated by adipocyte secreted VEGG, suggesting a complex paracrine relationships between microvascular endothelial cells and preadipocytes during tissue development.HAMEC from Gentaur Research Laboratories are isolated from human adipose tissue. HAMEC are cryopreserved after purification and delivered frozen. Each vial contains 1 x 10^6 cells in 1 ml volume. HAMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CD31 (P-CAM) and by uptake of DiI-Ac-LDL. HAMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAMEC are guaranteed to further expand for 15 population doublings at the conditions provided by Gentaur Research Laboratories.

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ABC-TC3479

Human Adrenal Microvascular Endothelial Cells

The adrenal gland plays an essential role in regulating homeostasis in the body through the secretion of corticosteroid and androgen hormones. The secreted steroids arise from three zones that form the adrenal gland: the zona glomerulosa, zona fasciculate, and zona reticularis. Microvascular endothelial cells line the blood vessels and contribute to many biological processes such as hemostasis, coagulation, trafficking of lymphocytes, and the inflammatory response. Microvascular endothelial cells (MEC) are of importance in the adrenal gland for their regulatory function on the secretion of adrenal hormones. Studies have shown that factors secreted from HAdMEC, such as endothelin-1, nitric oxide, adrenomedullin and PAMP affect aldosterone secretion. HAdMEC differ from MECs from different organs in function and phenotype. For example, compared to brain MEC and liver MEC, adrenal MEC are highly resistant to glucocorticoid-induced cytotoxicity showing that MECs are specialized to the tissues they belong to. HAdMEC from Gentaur Research Laboratories are isolated from human adrenal tissue. HAdMEC are cryopreserved at passage one and delivered frozen. Each vial contains 5×10 5 cells in 1 ml volume. HAdMEC are characterized by immunofluorescent method with antibodies to vWF/Factor VIII and CED31 (P-CAM). HAdMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAdMEC are guaranteed to further culture for 15 population doublings in the conditions provided by Gentaur Research Laboratories

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ABC-TC3513

Human Bladder Microvascular Endothelial Cells

The walls of capillaries are composed of a single layer of microvascular endothe-lial cells. These cells differ in morphology and other properties depending on the tissues the capillaries supply. Therefore, Gentaur offers a range of Microvascular Endothelial Cells produced at Gentaur's cell culture facility from normal human tissues of different origins.Shortly after isolation, all Gentaur Microvascular Endothelial Cells are cryopreserved at passage 2 (P2) using Gentaur's proprietary, serum-free freezing medium, Cryo-SFM. Each cryo vial contains more than 500,000 viable cells after thawing.Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur.

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