Lymphocytic choriomeningitis mammarenavirus Nucleocapsid Protein（LCMV-NP）
401.98 €
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Catalog number: 1144 - NCP0160
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 100ug
NCP0160
Lymphocytic choriomeningitis mammarenavirus Nucleocapsid Protein（LCMV-NP）
Lymphocytic choriomeningitis virus (LCMV) is an arenavirus, discovered by Armstrong and Lillie in 1933 that chronically infects small rodents. Humans can be infected by direct contact with rodents or their fomites, or by inhaling aerosolized particles. In immunocompetent adults, LCMV infection leads to an influenza-like illness or aseptic meningitis that usually resolves spontaneously; infection can also be asymptomatic. When women are infected during pregnancy, the virus can be transmitted to the embryo or fetus transplacentally. Infection causes risk for miscarriage; in utero fetal death; fetopathy, including severe central nervous system or ocular malformations; and severe neurologic sequelae. Little is known about the incidence and prevalence of LCMV.
401.98 €
NCP0167
Chapare mammarenavirus Nucleocapsid Protein(CHAPV-NP)
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
401.98 €
NCP0133
Machupo mammarenavirus Nucleocapsid Protein（MACV）
Machupo virus (MACV) is a member of the NW complex of arenaviruses and is the causative agent of Bolivian hemorrhagic fever (HF). Human infections generally result from exposure to chronically infected rodents (Calomys callosus) , but human-to-human spread has been reported11. Bolivian HF is a febrile illness often associated with vascular leakage and occasional concomitant neurological manifestations. Infection can result in a systemic inflammatory response syndrome leading to multiple organ failure and death.
401.98 €
NCP0154
Rift Valley fever phlebovirus Nucleocapsid Protein（RVFV-NP）
Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that was first discovered in Kenya in 1930 and is now endemic throughout multiple African countries and the Arabian Peninsula. RVF virus primarily infects domestic livestock (sheep, goats, cattle) causing high rates of neonatal mortality and abortion, with human infection resulting in a wide variety of clinical outcomes, ranging from self-limiting febrile illness to life-threatening haemorrhagic diatheses, and miscarriage in pregnant women. Since its discovery, RVF has caused many outbreaks in Africa and the Arabian Peninsula with major impacts on human and animal health. However, options for the control of RVF outbreaks are limited by the lack of licensed human vaccines or therapeutics.