Human Tumor suppressor p53-binding protein 1 (TP53BP1) ELISA Kit
688.5 EUR
688.5 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 749 - KTE60155-48T
Produktkategori: Företag och industri > Vetenskap och laboratorium
Leverantör:
Gentaur
Storlek: 48T
Parameters
| Additional information | TP53BP1 has a predicted molecular mass of 217 kD and shows homology in its C-terminal 247 amino acids to the C terminus of the tumor suppressor protein BRCA1. TP53BP1 was present in both the cytoplasm and nucleus in some cells and only in the nucleus in others. Furthermore, there were 2 nuclear staining patterns, one homogeneous staining and the other dot staining.TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation. TP53BP1 played a partially redundant role in phosphorylation of the downstream checkpoint effector proteins BRCA1 and CHK2 but was required for the formation of BRCA1 foci in a hierarchical branched pathway for the recruitment of repair and signaling proteins to sites of DNA damage. |
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| Storage and shipping | Storage: The unopened kit should be stored at 2 - 8°C. After opening, please store refer to protocols.Shipping:Gel pack with blue ice. |
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