IHUTRAILTNFRSF10RMSIGGFCLY100UG

Human TRAIL / TNFRSF10 Recombinant Protein Mouse IgG Fc Tag Lyophilized

Human TRAIL / TNFRSF10 Recombinant Protein Mouse IgG Fc Tag Lyophilized

1481.16 €

MBS8433630-INQUIRE

Human TRAIL/TNFRSF10 Recombinant Protein Mouse IgG Fc Tag Lyophilized

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11-334

TRAIL / TNFRSF10 Recombinant Protein

TRAIL, also known as TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL, TNLG6A and TNF superfamily member 10. The TRAIL gene as a drug target, induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. TRAIL also binds the receptors DcR1 and DcR2, which do not contain a cytoplasmic domain (DcR1) or contain a truncated death domain (DcR2). DcR1 functions as a TRAIL-neutralizing decoy-receptor. The cytoplasmic domain of DcR2 is functional and activates NFkappaB. In cells expressing DcR2, TRAIL binding therefore activates NFkappaB, leading to transcription of genes known to antagonize the death signaling pathway and/or to promote inflammation.

1213.46 €

MBS8433421-INQUIRE

Human Siglec-10 Recombinant Protein Mouse IgG Fc Tag Lyophilized

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MBS8431494-INQUIRE

Human CD155/PVR Recombinant Protein Mouse IgG Fc Tag Lyophilized

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MBS8431543-INQUIRE

Human CD27/TNFRSF7 Recombinant Protein Mouse IgG Fc Tag Lyophilized

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