Human Pulmonary Bronchial/Tracheal Epithelial Cells

ABC-TC3770

Human Pulmonary Alveolar Epithelial Cells

Pulmonary alveolar epithelial cells (PAEpiC) are comprised of alveolar type I and type II epithelial cells, line more than 99% of the internal surface area of the lung. Type I cells are large squamous cells whose thin cytoplasmic extensions cover 95% of the internal surface area. They contain aquaporins and exhibit the highest osmotic water permeability of among all mammalian cells. Type II cells, which cover 2-5% of the surface area, produce, secrete, and recycle pulmonary surfactant. The currently accepted hypothesis is that Type II cells maintain pulmonary fluid homeostasis by regulating active Na+ transport in the lungs, whereas Type I cells are "inert" cells that provide solely a barrier function, rather than having active functions. Recent study indicates that Type I cells are also important in regulating ion and fluid transport. HPAEpiC from Gentaur Research Laboratories are isolated from human lung tissue. HPAEpiC are cryopreserved at primary culture and shipped with dry ice. Each vial contains 1 x 10^6 cells in 1 ml volume. HPAEpiC are characterized by immunofluorescent method with antibodies CK-18, -19, and vimentin. HPAEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HPAEpiC are guaranteed to further culture at the conditions provided by Gentaur Research Laboratories. However, this cell type is not recommended for expanding or long term cultures since the cells would differentiate into type I alveolar epithelial cells immediately after plating and type I alveolar epithelial cells do not proliferate in culture.

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cAP-0122

Human Pulmonary Small Airway Epithelial Cells

1041 €

cAP-0123

Human Pulmonary Lobar Bronchial Epithelial Cells

1041 €

CSC-C9381W

Human Stomach Epithelial Cells

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ABC-TC3570

Human Colonic Epithelial Cells

The colorectum is a major organ for both malignant and nonmalignant diseases. Cells that line the colonic mucosal surface form a major mechanical barrier that separates the host’s internal milieu from the external environment. In addition to the well-established role of epithelial cells in ion transport, these cells appear to function as an integral component of the mucosal immune system. Human colon epithelial cells can process and present antigens to T cells in vitro, and can be stimulated to express HLA class II and intercellular adhesion molecules in vivo. They also respond to a broad array of cytokines with altered gene expression and growth characteristics. In addition, normal colonic epithelial cells were found to express the integrin α3, α5, α6, β1 and β4 chains. HCoEpiC from Gentaur Research Laboratories are isolated from human colonic tissue. HCoEpiC are cryopreserved at passage one and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HCoEpiC are characterized by immunofluorescent method with antibodies to CK18 and CK19. HCoEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCoEpiC are guaranteed to further culture for 15 population doublings in the conditions provided by Gentaur Research Laboratories.

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ABC-TC3577

Human Corneal Epithelial Cells

The cornea is a unique tissue for two reasons: the transparency function and the synthesis of most of its proteins due to the cornea being an avascular tissue. The cornea consists of three distinct cell layers, the outer epithelium, the inner endothelium and the central stroma (the keratocytes). The corneal epithelium plays a role in the innate immune response by sensing the presence of pathogens and providing signals that activate the corneal defense system. It also highly expresses aldehyde dehydrogenase to protect against UV- and 4-hydroxynonenal-induced cellular damage. Corneal epithelial basal cell proliferation is controlled by a host of cytokines, e.g., epidermal growth factor, that activate their cognate receptors in the deeper layers of the epithelium. Instead of testing products in the eyes of animals, cultured corneal epithelial cells could be used for toxicology tests in in vitro models and for studying the molecular mechanisms involved in regulating human corneal epithelial cell differentiation.HCEpiC from Gentaur Research Laboratories are isolated from human cornea. HCEpiC are cryopreserved from passage one culture. Each vial contains 5×10^5 cells in 1 ml volume. HCEpiC are characterized by their cobble stone morphology in serum-free culture and immunofluorescent method with antibody to CK-18 and -19. HCEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCEpiC are guaranteed to further expand for 10 population doublings at the condition provided by Gentaur Research Laboratories.

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