Katalognummer: 535 - cAP-0500-002-04
Produktkategori: Företag och industri > Vetenskap och laboratorium
Storlek: 1Frozen Vial
ABC-SC0117T
The CHOPWT9 IPSCs were established by Sendai viral infection carrying reprogramming factors Oct3/4, Sox2, c-Myc, and Klf-4 of peripheral blood mononuclear cells collected from a healthy adult female. These cells are capable of in vivo tetratoma formation as tested on NOD/SCID mice. The CHOPWT9 IPSCs are valuable in the field of developmental biology as they are useful as a control for applications such as differentiation analyses to the three germ layers and derivative tissues.
ABC-SC0123T
CHD8 has a role in chromatin dynamic, transcription and cell survival in which it interacts with p53 to regulate cell cycle genes. It has been associated with developmental disorders like ASD (autism spectrum disorders). CHD8+/− iPSC were derived from skin fibroblasts obtained from a typically developing male control who had a normal karyotype, in which a CHD8 allele was knocked out using CRISPR/Cas9 gene editing. The two lines can be utilized by researchers interested in brain development, neurodevelopmental disorders, and cancer.