IHUCD279PD1NLRFCLY200UG

Human CD279 [PD-1] non-lytic Recombinant Protein Fc Tag Lyophilized

Human CD279 [PD-1] non-lytic Recombinant Protein Fc Tag Lyophilized

1553.88 €

MBS8431534-INQUIRE

Human CD279 [PD-1] non-lytic Recombinant Protein Fc Tag Lyophilized

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90-448

CD279 [PD-1] non-lytic Recombinant Protein

Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signaling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.

1270.73 €

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Mouse IL-22 non-lytic Recombinant Protein Fc Tag Lyophilized

Mouse IL-22 non-lytic Recombinant Protein Fc Tag Lyophilized

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IMSIL2NLRFCLY10UG

Mouse IL-2 non-lytic Recombinant Protein Fc Tag Lyophilized

Mouse IL-2 non-lytic Recombinant Protein Fc Tag Lyophilized

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Mouse IL-2 non-lytic Recombinant Protein Fc Tag Lyophilized

Mouse IL-2 non-lytic Recombinant Protein Fc Tag Lyophilized

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