GIPR/CRE Luciferase Reporter HEK293 Cell Line
15460.58 €
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Catalog number: 421 - 78589
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 2 vials
RC1009
GATA3 Luciferase Reporter-HEK293 Cell Line
The GATA3 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the GATA3 response element, so that the cell line is designed to measure the transcriptional activity of GATA3. As a zinc-finger transcription factor, GATA3 (GATA-binding protein 3) plays a critical role in early and late T cell differentiation, which regulates Th1/Th2 differentiation. GATA3 has been shown to induce Th2 differentiation and repress Th1 differentiation. GATA3 is also known to promote the secretion of IL-4, IL-5 and IL-13 from Th2 cells. The GATA3 induction by phorbol 12-myristate 13-acetate (PMA) is shown in Figure 1.
2976.67 €
RC1010
NFAT Luciferase Reporter-HEK293 Cell Line
The NFAT Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the Nuclear Factor of Activated T-cells (NFAT) response element, so that the cell line is designed to measure the transcriptional activity of NFAT. NFAT is a transcription factor originally found in activated T lymphocytes, and is now known to regulate not only T cell activation and differentiation but also the function of other immune cells including dendritic cells, B cells and megakaryocytes. The NFAT induction by calcium ionophore A23187 is shown in Figure 1.
2976.67 €
RC1014
STAT3 Luciferase Reporter-HEK293 Cell Line
The STAT3 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter under the transcriptional control of the STAT3 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT3. As a transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) is activated through phosphorylation at tyrosine 705 in response to various cytokines including IL-6, interferons, epidermal growth factor, hepatocyte growth factor and leukemia inhibitory factor. The phosphorylated STAT3 forms homodimers or heterodimers with STAT1, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT3 induction by IL-6 is shown in Figure 1.
7023.54 €
ABC-RC0111
Human NFAT Reporter Cell Line– HEK293
Human NFAT Reporter Cell Line is derived from HEK293. This reporter cell line is an ideal product to monitor the blogical ativity
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ABC-RC0122
Human SRE Reporter Cell Line - HEK293
Human SRE Reporter Cell Line is derived from HEK293. Application: • Monitor MAPK/ERK signaling pathway activity and SRF-mediated activity.• Screen for activators or inhibitors of the MAPK/ERK signaling pathway.
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ABC-RC0125
Human STAT3 Reporter Cell Line–HEK293
Human Stat3 Reporter Cell Line is derived from HEK293. This reporter cell line is an ideal product to monitor the blogical ativity
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_x000D_Figure 1. Illustration of the GIPR/CRE Luciferase Reporter HEK293 Cell line.