GGTI-286 (hydrochloride)
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Produktdetaljer
Katalognummer: 804 - HY-117935
Produktkategori: Företag och industri > Vetenskap och laboratorium
Leverantör:
Gentaur
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HY-117935
GGTI-286 (hydrochloride)
GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2].
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