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CD47 [Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit
1074.92 €
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product details
Catalog number: 716 - EP-138
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 96tests
![CD47 [Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit](/images/no-image-product-box.jpg "CD47 [Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit")
EP-138
CD47 [Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit
CD47 is a transmembrane protein, a cell surface glycoprotein molecule belonging to the immunoglobulin superfamily that binds to a variety of proteins, including integrins, thrombospondin 1, and signal regulatory protein-α (SIRPα). In recent years, accumulating data have demonstrated that the CD47-SIRP-α axis is a key immune checkpoint in different cancers, including hematological malignancies, similar to PD-1/PD-L1 in solid tumors. Cd47-sirpα blockade has become a next-generation immune checkpoint blocking strategy for various malignancies after PD-1/PD-L1.
1074.92 €
EP-138-96tests
CD47 [Biotinylated] : SIRP alpha Inhibitor Screening ELISA Kit
CD47 is a transmembrane protein, a cell surface glycoprotein molecule belonging to the immunoglobulin superfamily that binds to a variety of proteins, including integrins, thrombospondin 1, and signal regulatory protein-α (SIRPα). In recent years, accumulating data have demonstrated that the CD47-SIRP-α axis is a key immune checkpoint in different cancers, including hematological malignancies, similar to PD-1/PD-L1 in solid tumors. Cd47-sirpα blockade has become a next-generation immune checkpoint blocking strategy for various malignancies after PD-1/PD-L1.
1074.92 €
EP-102
CD47 : SIRP alpha [Biotinylated] Inhibitor Screening ELISA Assay Pair
Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
1008.87 €
79789
LAG3:FGL1[Biotinylated] Inhibitor Screening Assay Kit
The LAG3:FGL1[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of LAG3:FGL1. The key to this kit is the high sensitivity of detection of biotin-labeled FGL1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, LAG3 is attached on a nickel-coated 96-well plate. Next, biotinylated FGL1 is incubated with LAG3 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
1408.95 €
72025
CD137[Biotinylated]:CD137L Inhibitor Screening Assay Kit
The CD137:CD137L Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CD137:CD137L interaction. The key to this kit is the high sensitivity of detection of biotin-labeled CD137 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, CD137L is coated on a 96-well plate. Next, CD137-biotin is incubated with CD137L on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.
1863.45 €
72045
OX40[Biotinylated]:OX40L Inhibitor Screening Assay Kit
The OX40[Biotinylated]:OX40L Inhibitor Screening Assay Kit is designed for_x000D_screening and profiling inhibitors of OX40:OX40L interaction. The key to this kit is the high sensitivity of detection of biotinlabeled_x000D_OX40 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for_x000D_the assay. First, OX40L is coated on a 96-well plate. Next, OX40-biotin is incubated with OX40L_x000D_on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP_x000D_substrate to produce chemiluminescence, which can then be measured using a_x000D_chemiluminescence reader.