![CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit](/_ipx/q_100,fit_outside,s_360x255/images/no-image-product-box.jpg "CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit")
![CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit](/_ipx/_/images/no-image-product-box.jpg "CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit")
CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit
1246.66 €
In Stock
quantity
product details
Catalog number: 716 - EP-150-96tests
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 96tests
![CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit](/images/no-image-product-box.jpg "CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit")
EP-150
CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for B7-1 (CD80) and B7-2 (CD86). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
1246.66 €
EP-150-96tests
CD28 : B7-1 [Biotinylated] Inhibitor Screening ELISA Kit
T-cell-specific surface glycoprotein CD28 is also known as TP44, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for B7-1 (CD80) and B7-2 (CD86). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
1246.66 €
79973
CTLA4 [Biotinylated]:B7-1 Inhibitor Screening Assay Kit
The activation of naíve T cells requires two signals, the specific T cell receptor recognition of MHC/Antigen on the surface of the antigen-presenting cell (APC), and the binding of B7-1 (CD80) ligand on the APC with the CD28 receptor on the T cell surface. Conversely, binding of CTLA4 to B7-1 on the T-cell surface results in an inhibitory signal and prevents T-cell activation. CTLA4B7-1 interaction is an important drug target for the regulation of the host's response to cancer. The CTLA4 [Biotinylated]:B7-1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CTLA4:B7-1 signaling. The key to this kit is the high sensitivity of detection of biotin-labeled CTLA4 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, B7-1 is coated on a 96-well plate. Next, CTLA4[B] is incubated with B7-1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
1772.55 €
EP-120
PD-1 [Biotinylated] : PD-L2 Inhibitor Screening ELISA Kit
PD-L2, also known as CD273 or B7-DC, is a member of the B7 family protein with PD-L1, and it is the second important ligand that can bind pD-1 after PD-L1. The human PD-L2(B7-H2, CD273) gene is also located on chromosome 9p24, encoding type I transmembrane protein with 247 amino acids. The homology of PD-L1 and PD-L2 was 40%. The affinity between PD-L2 and PD-1 is 2-6 times that of PD-L1. Compared with PD-L1, the expression of PD-L2 is relatively limited, and pD-L2 is induced to express on the surface of dendritic cells, macrophages, bone marrow derived mast cells and other cells.
1074.92 €
EP-120-96tests
PD-1 [Biotinylated] : PD-L2 Inhibitor Screening ELISA Kit
PD-L2, also known as CD273 or B7-DC, is a member of the B7 family protein with PD-L1, and it is the second important ligand that can bind pD-1 after PD-L1. The human PD-L2(B7-H2, CD273) gene is also located on chromosome 9p24, encoding type I transmembrane protein with 247 amino acids. The homology of PD-L1 and PD-L2 was 40%. The affinity between PD-L2 and PD-1 is 2-6 times that of PD-L1. Compared with PD-L1, the expression of PD-L2 is relatively limited, and pD-L2 is induced to express on the surface of dendritic cells, macrophages, bone marrow derived mast cells and other cells.
1074.92 €
EP-130
PD-1 : PD-L1 [Biotinylated] Inhibitor Screening ELISA Kit
Immune checkpoint pathway is a focal point of today’s cancer research. PD-1 is one of the best characterized checkpoint proteins. The binding between PD-1 and its ligand PD-L1 suppresses T-cell activation and allows cancer cells to escape from body’s immune surveillance. Therefore, the pharmaceutical inhibition of PD-1 or its ligand has been considered a promising strategy by many oncologists.