B2M Knockout NFAT Luciferase Reporter Jurkat Cell Line
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Produktdetaljer
Katalognummer: 421 - 78363
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 2 vials
78557
TCR/B2M Knockout NFAT Luciferase Reporter Jurkat Cell Line
This cell line is a double knockout of TCR (T Cell Receptor) and B2M (Beta-2-Microglobulin). First, the TRAC (T-Cell Receptor Alpha Constant) and the TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα/β chains were genetically removed by CRISPR/Cas9 genome editing from NFAT Luciferase Reporter Jurkat cells to generate the TCR Knockout NFAT Luciferase Reporter Jurkat cell Line (BPS Bioscience #78556). These TCR knockout cells were used to generate a new cell line in which B2M was also genetically removed by CRISPR/Cas9 genome editing. _x000D_Expression of the firefly luciferase gene is driven by NFAT response elements located upstream of the minimal TATA promoter. Activation of the NFAT signaling pathway in these cells can be monitored by measuring luciferase activity.
25192.5 €
78342
B2M Knockout Jurkat Cell Line
B2M (Beta-2-Microglobulin) has been genetically removed by CRISPR/Cas9 genome editing from Jurkat cells.
9900 €
78556
TCR Knockout NFAT-Luciferase Reporter Jurkat Cell Line
This cell line is a knockout of TCR (T Cell Receptor). The TRAC (T-Cell Receptor Alpha Constant) and TRBC1 (T-Cell Receptor Beta Constant 1) domains of the TCRα/β chains were genetically removed by CRISPR/Cas9 genome editing from recombinant Jurkat cells stably expressing the firefly luciferase gene under the control of NFAT response elements.This cell line has been functionally validated and does not respond to anti-CD3 agonist antibodies, as opposed to parental NFAT-Luciferase Reporter Jurkat cells (BPS Bioscience #60621).
18457.5 €
AKR-208
T47D/GFP Cell Line
T47D/GFP Cell Line stably expresses GFP and otherwise exhibits the same characteristics of the parental cell line.
1038.59 €
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