anti- KPNA2 antibody
1059.45 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 710 - FNab04635
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 100µg
Parameters
| Additional information | Immunogen: karyopherin alpha 2(RAG cohort 1, importin alpha 1);Uniprot ID: P52292;Gene ID: 3838;Research Area: Cancer, Metabolism |
|---|---|
| Storage and shipping | anti- KPNA2 antibody should be stored in PBS with 0.02% sodium azide and 50% glycerol pH 7.3 should be stored at -20℃ for 12 months after the date of manufacture. PLease avoid repeated freeze/ thaw cycles in order not to damage the product structure. |
STJ24341
Anti-KPNA2 antibody
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.
648.6 €
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