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Anti-CD8a Antibody [2.43], PerCP-Cy5.5-100ug
744.17 €
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Catalog number: 10119 - QAB61-PCP55-100ug
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 100ug
RD21257F-100Tests
PerCP/Cyanine5.5 Anti-Mouse CD8a Antibody
CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.