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Anti-CD3 Antibody [OKT3], PerCP-Cy5.5-100Tests
684.17 €
In Stock
quantity
product details
Catalog number: 10119 - QAB5-PCP55-100Tests
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 100Tests
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GMP-MC0323
GMP Monoclonal Anti-Human CD3 Antibody (OKT3)
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.