91-579

TNF RII Recombinant Protein

Tumor Necrosis Factor Receptor Superfamily Member 1B (TNFRSF1B) is a member of the Tumor Necrosis Factor Receptor Superfamily. TNFRSF1B contains four TNFR-Cys repeats. TNFRSF1B can be cleaved into the following 2 chains: Tumor necrosis factor receptor superfamily member 1b and membrane form and Tumor necrosis factor-binding protein 2. TNFRSF1B is a receptor with high affinity for TNFSF2/TNF- alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin- alpha. TNFRSF1B mediates most of the metabolic effects of TNF- alpha. TNF- alpha-induced apoptosis suggests that it regulates TNF- alpha function by antagonizing its biological activity.

1022.58 €

92-344

TNF RII Recombinant Protein

Tumor necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumor necrosis factor receptor) superfamily characterized by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

1118.02 €

92-700

TNF RII Recombinant Protein

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNF alpha and Lymphotoxin alpha/TNF beta ;soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.

1022.58 €

IHUMISRIIRFCLY100UG

Human MIS RII Recombinant Protein Fc Tag Lyophilized

Human MIS RII Recombinant Protein Fc Tag Lyophilized

1481.16 €

E40KMH1818

Recombinant Human TNF RII/TNFRSF1B Protein, His Tag

901.42 €

MBS2556725-001mg

Recombinant Human Low Affinity Fc Epsilon RII Protein

405.77 €