This line was isolated from ascitic fluid of a 70-year-old Caucasian male with adenocarcinoma of the colon. The patient had been treated with 5-fluorouracil for 4-6 weeks before removal of the fluid specimen.
Mouse squamous cell carcinoma. Cells produce metastases in the lungs when inoculated intravenously into DBA/2 or BDF1 mice. The cells are a potential model for chemotherapeutic screening.
TMC-205 is a natural fungal metabolite with antiproliferative activity against cancer cell lines. TMC-205 is a transcriptional up-regulator of SV40 promoter[1].