78027

IL-6:IL-6R Inhibitor Screening Assay Kit

Interleukin 6 (IL-6), and its receptor complex interleukin 6 receptor (IL-6R, CD126)-gp130 (CD130), play an important role in immune response. Elevated IL-6 leads to an acute severe systemic inflammatory response known as 'cytokine storm', where an uncontrolled and excessive release of pro-inflammatory cytokines can cause multisystem organ failure and death. Mortality in COVID-19 patients has been linked to this severe response induced by the virus. Tocilizumab is a humanized monoclonal antibody against the IL-6R used as immunosuppressive drug, and it is emerging as an alternative treatment for COVID-19 patients at risk for 'cytokine storm'._x000D_<br />The IL-6:IL-6R Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this receptor-ligand interaction. The key to this kit is the high sensitivity of detection of IL-6-Biotin protein by Streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, IL-6R protein is attached to a nickel-coated 96-well plate. Next, IL-6-Biotin incubated with IL-6R on the plate. Finally, the plate is treated with Streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which then can be measured using a chemiluminescence reader.

1357.50 €

78501

Fc (IgG1): FcRn Inhibitor Screening Colorimetric Assay Kit

The Fc (IgG1): FcRn Inhibitor Screening Colorimetric Assay Kit is designed for screening and profiling neutralizing antibodies or inhibitors of the interaction between Fc (IgG1) and human FcRn. _x000D_The assay requires only a few steps. First, Fc (IgG1) is coated on a 96-well plate overnight. After blocking, the protein is pre-incubated with the inhibitor or neutralizing antibody. Upon subsequent incubation with Biotin-FcRn, the plate is treated with Streptavidin-HRP followed by addition of a colorimetric HRP substrate to produce color, which can be quenched and measured using a UV/Vis microplate reader.

1395.00 €

72060

IL-17RA[Biotin]:IL-17A Inhibitor Screening Assay Kit

The IL-17RA[Biotin]:IL-17A Inhibitor Screening Assay Kit is designed for_x000D_screening inhibitors of IL-17A:IL-17RA interaction. The IL-17RA[Biotin]-IL-17A Binding Assay Kit_x000D_comes in a convenient 96-well format, with biotin-labeled IL-17RA, purified IL-17A, streptavidinlabeled_x000D_HRP, and assay buffer for 100 binding reactions. The key to this kit is the high_x000D_sensitivity of detection of biotin-labeled IL-17RA by streptavidin-HRP. Only a few simple steps_x000D_on a microtiter plate are required for the assay. First, IL-17A is coated on a 96-well plate. Next,_x000D_IL-17RA is incubated with IL-17A on the plate. Finally, the plate is treated with streptavidin-HRP_x000D_followed by addition of an HRP substrate to produce chemiluminescence, which can then be_x000D_measured using a chemiluminescence reader.

2017.50 €

K989-100

Plasma Kallikrein Inhibitor Screening Kit (Colorimetric)

1316.40 €

K247-100

Dihydrofolate Reductase Inhibitor Screening Kit (Colorimetric)

1316.40 €

K2043-100

Human GAPDH Inhibitor Screening Kit (Colorimetric)

1231.80 €