SARS-CoV-2 (COVID-19) ORF3A Recombinant Protein
1232.55 €
In Stock
quantity
product details
Catalog number: 223 - 20-242
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 0.1 mg
20-196
SARS-CoV-2 (COVID-19) ORF3A Recombinant Protein
SARS-CoV-2 (COVID-19) ORF3A Recombinant Protein
1232.55 €
10-005
SARS-CoV-2 (COVID-19) ORF3a Recombinant Protein
LOCUS: QHD43417 275aa linear VRL 18-MAR-2020<br> DEFINITION: ORF3a protein [Severe acute respiratory syndrome coronavirus 2]<br> ACCESSION: QHD43417 VERSION:QHD43417.1<br> DBSOURCE: accession MN908947.3<br> SOURCE: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) <br> ORGANISM: Viruses, Riboviria, Nidovirales, Cornidovirineae, Coronaviridae,Orthocoronavirinae, Betacoronavirus, Sarbecovirus.
1213.46 €
9275-002mg
SARS-CoV-2 (COVID-19) ORF3a Antibody
Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019–20 coronavirus outbreak (2). SARS-CoV-2 virus proteins include structural proteins, non-structural proteins and accessory factors. The structure of SARS-CoV-2 consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. SARS-CoV-2 non-structural protein is ORF1ab that consists of 16 proteins (nsp1-nsp16), while accessory factors include ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10. ORF3a forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. It up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. It induces apoptosis in cell culture and downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination (3).
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