Ruxolitinib . phosphate salt
415.95 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 862 - GW4048-25
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 25
Parameters
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|---|
10-043
Ruxolitinib . phosphate salt
Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19)
711.94 €
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