Catalog number: 607 - B7810-25
Product Category: Business & Industrial > Science & Laboratory
Size: 25 mg
B1273-25
RK-33 is an inhibitor of DEAD box 3 (DDX3), an ATP-dependent RNA helicase. RK-33 inhibits the growth of lung cancer cells that overexpress DDX3 (IC₅₀s = 4.4-8.4 µM) but is less effective in cells with low DDX3 expression (IC₅₀ > 25 µM). It also promotes radiation sensitization in cells overexpressing DDX3. RK-33 in combination with radiation induces tumor regression in multiple animal models of lung cancer.
B1273-5
RK-33 is an inhibitor of DEAD box 3 (DDX3), an ATP-dependent RNA helicase. RK-33 inhibits the growth of lung cancer cells that overexpress DDX3 (IC₅₀s = 4.4-8.4 µM) but is less effective in cells with low DDX3 expression (IC₅₀ > 25 µM). It also promotes radiation sensitization in cells overexpressing DDX3. RK-33 in combination with radiation induces tumor regression in multiple animal models of lung cancer.