RecombinantNT-4,Mouse
594.6 EUR
594.6 EUR
In Stock
quantity
Produktdetaljer
Katalognummer: 965 - BK0145
Produktkategori: Företag och industri > Vetenskap och laboratorium
Leverantör:
Gentaur
Storlek: 10μg
Parameters
| Additional information | Neurotrophin-4 (NT-4) is a small secreted cytokine, and belongs to the Neurotrophin (NT) family, which also includes Brain Derived Neurotropic Factor (BDNF), Nerve Growth Factor (NGF), and NT-3. NT family members are all derived from similar sized protein precursors, composed of N-terminal propeptides and C-terminal mature domains, which are separated by posttranslational proteolytic cleavage. NT-4 (along with NT-3) is foundin the brains of mammals . In vivo, NT-4 binds to the common receptor, p75NTR, and a tyrosine kinase receptor, TrkB. The heterotrimeric complex activates the NFκB transcription factor. NT-4 is essential for the differentiation and wiring regulation of the central and peripheral nervous systems during development, and is related to important diseases including Alzheimer’s.Recombinant mouse Neurotrophin-4 (rmNT-4) produced in E.coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chainsof 131 amino acids. A fully biologically active molecule, rmNT-4 has a molecular mass of 14.0kDaanalyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript. |
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BK0145
RecombinantNT-4,Mouse
ED50 <1µg/mL, measured by a cell proliferation assay usingC6cells, corresponding to a specific activity of>1× 10ˆ3 units/mg.
594.6 €
BK0145
RecombinantNT-4,Mouse
ED50 <1µg/mL, measured by a cell proliferation assay usingC6cells, corresponding to a specific activity of>1× 10ˆ3 units/mg.
228 €
BK0144
RecombinantNT-4,Human
ED50 < 5.0 μg/ml, measured by a cell proliferation assay using C6 cells, corresponding to a specific activity of > 2.0× 10ˆ2 units/mg.
594.6 €
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