R-268712
0.01 EURAsk for quotation
0.01 EURAsk for quotation
On request
quantity
Produktdetaljer
Katalognummer: 931 - T16708-5mg
Produktkategori: Företag och industri > Vetenskap och laboratorium
Leverantör:
Gentaur
Storlek: 5mg
Parameters
| Additional information | SMILES: FC1=CC=C(C=C1C=2C=NN(C2)CCO)C3=CNN=C3C=4N=C(C=CC4)C; Formula: C20H18FN5O |
|---|
HY-12953
R-268712
R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer[1][2].
727.35 €
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