Phospho-MYC (Thr58) Antibody
1983.26 €
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Catalog number: 544 - MBS7133250-5x01mL
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 5x0.1mL
BT-AP06916-100ul
c-Myc(Phospho Thr58) Polyclonal Antibody
The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.