OKCD00874-96W - VCP ELISA Kit (Human)

OKCD00874-96W

OKCD00874-96W - VCP ELISA Kit (Human)

1169.5 €

OKCD01684-96W

OKCD01684-96W - Vcp ELISA Kit (Rat)

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OKCD00874

VCP ELISA Kit (Human) (OKCD00874)

Description of target: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022).By similarity&#xd; &lt;p>Manually curated information which has been propagated from a related experimentally characterized protein.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000250">More…&lt;/a>&lt;/p> Manual assertion inferred from sequence similarity toiUniProtKB:P46462&nbsp;(TERA_RAT)9 Publications&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.14"Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders."_x005F_x005F_x000D_Ishigaki S., Hishikawa N., Niwa J., Iemura S., Natsume T., Hori S., Kakizuka A., Tanaka K., Sobue G._x005F_x005F_x000D_J. Biol. Chem. 279:51376-51385(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH RNF19A, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-524.Ref.18"Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase."_x005F_x005F_x000D_Song B.L., Sever N., DeBose-Boyd R.A._x005F_x005F_x000D_Mol. Cell 19:829-840(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH AMFR, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-251 AND LYS-524.Ref.39"The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover."_x005F_x005F_x000D_Xu S., Peng G., Wang Y., Fang S., Karbowski M._x005F_x005F_x000D_Mol. Biol. Cell 22:291-300(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN OMM PROTEIN TURNOVER.Ref.44"The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks."_x005F_x005F_x000D_Meerang M., Ritz D., Paliwal S., Garajova Z., Bosshard M., Mailand N., Janscak P., Hubscher U., Meyer H., Ramadan K._x005F_x005F_x000D_Nat. Cell Biol. 13:1376-1382(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.45"The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks."_x005F_x005F_x000D_Acs K., Luijsterburg M.S., Ackermann L., Salomons F.A., Hoppe T., Dantuma N.P._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 18:1345-1350(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH L3MBTL1.Ref.47"STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein."_x005F_x005F_x000D_Sato T., Sako Y., Sho M., Momohara M., Suico M.A., Shuto T., Nishitoh H., Okiyoneda T., Kokame K., Kaneko M., Taura M., Miyata M., Chosa K., Koga T., Morino-Koga S., Wada I., Kai H._x005F_x005F_x000D_Mol. Cell 47:99-110(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN ERAD PATHWAY.Ref.50"DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage."_x005F_x005F_x000D_Davis E.J., Lachaud C., Appleton P., Macartney T.J., Nathke I., Rouse J._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 19:1093-1100(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SPRTN.Ref.51"DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks."_x005F_x005F_x000D_Mosbech A., Gibbs-Seymour I., Kagias K., Thorslund T., Beli P., Povlsen L., Nielsen S.V., Smedegaard S., Sedgwick G., Lukas C., Hartmann-Petersen R., Lukas J., Choudhary C., Pocock R., Bekker-Jensen S., Mailand N._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 19:1084-1092(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SPRTN.Ref.62"VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD."_x005F_x005F_x000D_Tresse E., Salomons F.A., Vesa J., Bott L.C., Kimonis V., Yao T.P., Dantuma N.P., Taylor J.P._x005F_x005F_x000D_Autophagy 6:217-227(2010) [PubMed] [Europe PMC] [Abstract]Cited for: CHARACTERIZATION OF VARIANTS IBMPFD1 HIS-155; SER-155 AND GLU-232, MUTAGENESIS OF GLU-305 AND GLU-578, FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.112 ng/mL

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