Mitofusin-2 (MFN2) Antibody
870.22 €
870.22 €
In Stock
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product details
Catalog number: 639 - abx235151-100ug
Product Category: Business & Industrial > Science & Laboratory
Supplier:
Gentaur
Size: 100 ug
7863-002mg
MFN2 Antibody
Mitofusin 2 (MFN2) and the related protein MFN1 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2). MFN2 is ubiquitously expressed, and found in both the ER and outer mitochondrial membrane. MFN2 has two key domains: a coiled coil region that mediates MFN2 binding and a GTPase domain that likely plays a role in fusion (3,4). Both domains are essential for embryonic development and may play a role in the pathobiology of obesity. Overexpression of MFN2 causes mitochondrial dysfunction and cell death (5).