90-511

IL-21 mutant Recombinant Protein

Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumors, leading to tumor rejection that is perforin dependent but IFN-gamma independent.

1375.72 €

IHUIL21MTRHISLY10UG

Human IL-21 mutant Recombinant Protein His Tag Lyophilized

Human IL-21 mutant Recombinant Protein His Tag Lyophilized

917.59 €

IHUIL21MTRHISLY50UG

Human IL-21 mutant Recombinant Protein His Tag Lyophilized

Human IL-21 mutant Recombinant Protein His Tag Lyophilized

1688.72 €

MBS1352672-01mgEColi

Recombinant Anopheles gambiae Protein mab-21 (mab-21)

1584.06 €

MBS1352672-01mgYeast

Recombinant Anopheles gambiae Protein mab-21 (mab-21)

1699.95 €

MBS1246338-002mgBaculovirus

Recombinant Mycobacterium phage D29 Gene 21 protein (21)

1519.67 €