Human IL-15 R alpha Recombinant Protein
537 EUR
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quantity
Produktdetaljer
Katalognummer: 519 - PROTQ13261
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: Regular: 10ug
92-484
IL-15 R alpha Recombinant Protein
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.
691.15 €
92-530
IL-15 R alpha Recombinant Protein
Interleukin 15 Receptor alpha (IL-15R alpha) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15R alpha chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15R alpha can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15R alpha complexes exhibit a strong agonistic activity which is mediated through membrane-bound IL-15 receptor beta and gamma heterodimers and enables signaling to cells.
1239.25 €
92-588
IL-15 R alpha & IL-15 fusion protein Recombinant Protein
Interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il15ra shares 45% amino acid sequence homology with the mouse form of the receptor. Eight isoforms of IL-15 R alpha mRNA have been identified, resulting from alternative splicing events involving different exons.Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.
1106.95 €
PROTP21183
Mouse IL-5 R alpha Recombinant Protein
Mouse IL-5 R alpha Recombinant Protein expressed in Baculovirus with His-tag. Sequence domain: 18-339aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).
525 €
ILA-H5253
Human IL-15 R alpha / CD215 Protein, Fc Tag (MALS verified)
Human IL-15 R alpha, Fc Tag (ILA-H5253) is expressed from human 293 cells (HEK293). It contains AA Ile 31 - Thr 205 (Accession # Q13261-1).
3222.48 €
VAng-1778Lsx-100g
Human IL-15 R alpha Protein (Ile 31-Thr 205) [Fc]
Human IL-15 R alpha (CD215), Fc tag, is expressed in human 293 cells. (Uniprot ID: Q13261-1)