![FRK Mouse Monoclonal Antibody [Clone 7A7]](/_ipx/q_100,fit_outside,s_360x255/images/no-image-product-box.jpg "FRK Mouse Monoclonal Antibody [Clone 7A7]")
![FRK Mouse Monoclonal Antibody [Clone 7A7]](/_ipx/_/images/no-image-product-box.jpg "FRK Mouse Monoclonal Antibody [Clone 7A7]")
FRK Mouse Monoclonal Antibody [Clone 7A7]
446.93 €
446.93 €
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quantity
product details
Catalog number: 426 - E45M09216V-2
Product Category: Business & Industrial > Science & Laboratory
Supplier:
Gentaur
Size: 50 ul
![C4orf36 Mouse Monoclonal Antibody [Clone:7A7]](/images/no-image-product-box.jpg "C4orf36 Mouse Monoclonal Antibody [Clone:7A7]")
RF16083-002mg
LAG3 Antibody [7A7]
The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.