Equine IL-1ra Recombinant Protein
622.36 €
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Catalog number: 519 - R00651-4
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 5ug/vial
92-517
IL-1RA Recombinant Protein
Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and IL-1 alpha, respectively. Il1rn can Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling, but has no interleukin-1 like activity. Recently, an recombinant human Il1rn protein is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.
1375.72 €
91-024
IL-1RA Recombinant Protein
Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.
698.06 €
PROTP25085
Mouse IL-1ra/IL-1F3 Recombinant Protein
Mouse IL-1ra/IL-1F3 Recombinant Protein expressed in E. coli with His-tag. Sequence domain: 27-178aa. Application(s): SDS-PAGE, Bioactivity. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method).
519.64 €
PROTP25086
Rat IL-1ra/IL-1F3 Recombinant Protein
Rat IL-1ra/IL-1F3 Recombinant Protein expressed in E. coli with His-tag. Sequence domain: 27-178aa. Application(s): SDS-PAGE.