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CTLA4 : B7-2[Biotinylated] Inhibitor Screening Assay Kit
1977.08 €
In Stock
quantity
product details
Catalog number: 421 - 79658
Product Category: Business & Industrial > Science & Laboratory
Gentaur
Size: 96 rxns.
![CTLA4 [Biotinylated]:B7-1 Inhibitor Screening Assay Kit](/images/no-image-product-box.jpg "CTLA4 [Biotinylated]:B7-1 Inhibitor Screening Assay Kit")
79973
CTLA4 [Biotinylated]:B7-1 Inhibitor Screening Assay Kit
The activation of naíve T cells requires two signals, the specific T cell receptor recognition of MHC/Antigen on the surface of the antigen-presenting cell (APC), and the binding of B7-1 (CD80) ligand on the APC with the CD28 receptor on the T cell surface. Conversely, binding of CTLA4 to B7-1 on the T-cell surface results in an inhibitory signal and prevents T-cell activation. CTLA4B7-1 interaction is an important drug target for the regulation of the host's response to cancer. The CTLA4 [Biotinylated]:B7-1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CTLA4:B7-1 signaling. The key to this kit is the high sensitivity of detection of biotin-labeled CTLA4 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, B7-1 is coated on a 96-well plate. Next, CTLA4[B] is incubated with B7-1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
1772.55 €
72007
CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit
The CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CD28:B7-1 signaling. The key to this kit is the high sensitivity of detection of biotin-labeled B7-1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, CD28 is coated on a 96-well plate. Next, B7-1 is incubated with CD28 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
1772.55 €
72009
CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit
The CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CTLA4:B7-1 signaling. The key to this kit is the high sensitivity of detection of biotin-labeled B7-1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, CTLA4 is coated on a 96-well plate. Next, B7-1 is incubated with CTLA4 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
1855.88 €
79971
Cathepsin F Inhibitor Screening Assay Kit
The Cathepsin F Inhibitor Screening Assay Kit is designed to measure the protease activity of Cathepsin F for screening and profiling applications.
931.73 €
32513
BRD3 (BD1) Inhibitor Screening Assay Kit
The BRD3 (BD1) Inhibitor Screening Assay Kit is designed to measure the inhibition of BRD3 bromodomain 1 (BD1) from binding to its substrate. The key to the BRD3 (BD1) Inhibitor Screening Assay Kit is the highly specific binding of the BRD3 bromodomain 1 to the acetylated histone substrate. With this kit, only three simple steps on a microtiter plate are required. First, a sample containing BRD3 bromodomain 1 and an inhibitor of choice is incubated with the biotinylated substrate for thirty minutes. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.
924.15 €
32514
BRD4 (BD1) Inhibitor Screening Assay Kit
The BRD4 (BD1) Inhibitor Screening Assay Kit is designed to measure the inhibition of BRD4 bromodomain 1 (BD1) from binding to its substrate. The key to the BRD4 (BD1) Inhibitor Screening Assay Kit is the highly specific binding of the BRD4 bromodomain 1 to the acetylated histone substrate. With this kit, only three simple steps on a microtiter plate are required. First, a sample containing BRD4 bromodomain 1 and an inhibitor of choice is incubated with the biotinylated substrate for thirty minutes. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.