CM-272 is a first-in-class reversible dual inhibitor against G9a and DNMTs with IC50 values of 8 nM and 382 nM, respectively [1].G9a is a histone methyltransferase that is overexpressed in many tumors.
CM-272 is a first-in-class reversible dual inhibitor against G9a and DNMTs with IC50 values of 8 nM and 382 nM, respectively [1].G9a is a histone methyltransferase that is overexpressed in many tumors.