Catalog number: 607 - E1010-25
Product Category: Business & Industrial > Science & Laboratory
Size: 25 units
E1010-100
Caspase-1, expressed in E. coli, suitable for cell culture.
E1010-25
Caspase-1 belongs to the caspase-family of cysteine proteases. Caspase-1 exists in cells as an inactive proenzyme. The molecular mass of the proenzyme is 45 kDa.
CD00406-10ug
The insulin-like growth factors (IGFs) belonged to the insulin gene family, are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. The production of IGF-1 is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B. Recombinant Mouse IGF-1 are globular proteins containing 70 amino acids and 3 intra-molecular disulfide bonds. Mature Mouse IGF-1 shares 94 % and 98 % a.a. sequence identity with human and rat IGF-1, respectively.
S01-M05S
VCAM is a 110 kDa, cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development of several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant Murine VCAM-1 is a 74.4 kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 87-97 kDa by SDS-PAGE analysis under reducing conditions.