Catalog number: 716 - SPD-C82H7
Product Category: Business & Industrial > Science & Laboratory
Size: 200ug
SPD-S164
S protein has two functional regions, S1 and S2. S1 is composed of four domains, including N-amino-terminal domain (NTD) and receptor-binding domain (RBD), and binds to host cell receptor ACE2. Compared with RBD antibody, the neutralization ability of NTD antibody is weak, most of which can recognize the three-dimensional conformation of viral protein. In the NTD region of mutant strains, there are a large number of amino acid deletion and insertion, as well as numerous point mutations, most of which can escape the recognition and neutralization of NTD antibody.
SPD-C522h
SARS-CoV-2 Spike NTD, His Tag (BA.2/Omicron) (SPD-C522h) is expressed from human 293 cells (HEK293). It contains AA Ser 13 - Leu 303 (Accession # QHD43416.1(T19I, LPP24-26del, A27S, G142D, V213G)). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.2; GISAID clade: GRA; Nextstrain clade: 21L).
SPD-C522h-100ug
SARS-CoV-2 Spike NTD, His Tag (BA.2/Omicron) (SPD-C522h) is expressed from human 293 cells (HEK293). It contains AA Ser 13 - Leu 303 (Accession # QHD43416.1(T19I, LPP24-26del, A27S, G142D, V213G)). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.2; GISAID clade: GRA; Nextstrain clade: 21L).
SPN-C5248
SARS-CoV-2 Spike Trimer, His Tag (XBB/Omicron) (SPN-C5248) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1 (T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P). The spike mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: XBB). The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
SPN-C52Hm
SARS-CoV-2 S protein (K417N,D614G), His Tag (SPN-C52Hm) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The mutations (K417N, D614G) were identified in the SARS-CoV-2 variant (known as B.1.351 or 20C/501Y.V2) which emerged in South Africa. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
SPN-C52Hm-500ug
SARS-CoV-2 S protein (K417N,D614G), His Tag (SPN-C52Hm) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1). The mutations (K417N, D614G) were identified in the SARS-CoV-2 variant (known as B.1.351 or 20C/501Y.V2) which emerged in South Africa. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) and alanine substitutions (R683A and R685A) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.